GENERAL NEWS – FLUCLOXACILLIN (FLOXACILLIN; ANTI(MYCO)BACTERIAL) ADDED TO FUNGAL PHARMACOLOGY

Significant interaction with voriconazole

07/04/2015 - A new interacting agent has been added to Fungal Pharmacology: Flucloxacillin (Floxacillin; anti(myco)bacterial: clinically significant interaction with voriconazole).

A case report described undetectable voriconazole concentrations (400 mg daily) voriconazole after the start of therapy with 2 g flucloxacillin intravenously four times a day. Despite intravenous or increasingly higher oral dosing, voriconazole plasma concentrations remained undetectable until the flucloxacillin was ceased.

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