DRUG INTERACTION BETWEEN ISAVUCONAZOLE AND TACROLIMUS

A case report indicating the need for tacrolimus drug-level monitoring

15/09/2015 - This case reports describes a patient with a mediastinal Aspergillus fumigatus infection resistant to posaconazole who is successfully managed with tacrolimus therapeutic drug-level monitoring. It was concluded that when isavuconazole is given to patients on tacrolimus, the dose of the latter will need considerable reduction. An initial 50% reduction and close weekly monitoring of tacrolimus concentration is recommended. Further dose decreases of 25-50% may be required.

Drug-drug interaction between isavuconazole and tacrolimus: a case report indicating the need for tacrolimus drug-level monitoring

Kim T, Jancel T, Kumar P, Freeman AF

J Clin Pharm Ther. 2015 Aug 6

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