ARTICLE - Understanding Variability in Posaconazole Exposure Using an Integrated Population Pharmacokinetic Analysis

08/09/2014 - Posaconazole oral suspension is widely used for antifungal prophylaxis and treatment in immunocompromised patients, with highly variable pharmacokinetics reported in patients due to inconsistent oral absorption. This study aimed to characterise the pharmacokinetics of posaconazole in adults and investigate factors that influence posaconazole pharmacokinetics using a population pharmacokinetic approach.

Understanding Variability in Posaconazole Exposure Using an Integrated Population Pharmacokinetic Analysis.

Dolton MJ, Br├╝ggemann RJ, Burger DM, McLachlan AJ.

Antimicrob Agents Chemother. 2014 Sep 8.

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