ARTICLE - NO SIGNIFICANT INTERACTION BETWEEN ITRACONAZOLE AND TRAMADOL

A randomised placebo-controlled crossover study in 12 healthy subjects showed itraconazole has no meaningful interaction with tramadol in subjects who have functional CYP2D6 enzyme

22/05/2015 - A randomised placebo-controlled crossover study in 12 healthy subjects (8 extensive, 4 ultra-rapid CYP2D6 metabolisers) receiving itraconazole (200 mg/day for 5 days) described no significant change in the pharmacokinetics of tramadol (50 mg single, oral dose on day 4). This article confirmed earlier findings in literature.

Effects of terbinafine and itraconazole on the pharmacokinetics of orally administered tramadol

Saarikoski T, Saari TI, Hagelberg NM et al.

Eur J Clin Pharmacol. 2015 Mar;71(3):321-7.

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