ARTICLE - INTERACTION BETWEEN VORICONAZOLE AND FLUCLOXACILLIN

A case report of undetectable voriconazole concentrations when flucloxacillin was administered concomitantly

07/04/2015 - A case report described undetectable voriconazole concentrations (400 mg daily) voriconazole after the start of therapy with 2 g flucloxacillin intravenously four times a day. Despite intravenous or increasingly higher oral dosing, voriconazole plasma concentrations remained undetectable until the flucloxacillin was ceased.

Interaction between voriconazole and flucloxacillin during treatment of disseminated Scedosporium apiospermum infection

Kennedy B, Larcombe R, Chaptini C, Gordon DL.

J Antimicrob Chemother. 2015 Mar 15. pii: dkv069.

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