ARTICLE - DRUG-DRUG INTERACTION BETWEEN ITRACONAZOLE AND RIFAMPICIN / RIFABUTIN

Significantly lower itraconazole plasma concentrations when coadministered with rifampicin / rifabutin

31/07/2015 - In patients with chronic pulmonary aspergillosis, serum itraconazole concentrations were found to be significantly lower when coadministered with rifampin (median, 0.1 μg/ml; P < 0.001) or rifabutin (median, 0.34 μg/ml; P < 0.001) than patients receiving itraconazole alone (median, 5.92 μg/ml). It was concluded that concomitant use of rifampin or rifabutin and itraconazole should be avoided in patients with chronic pulmonary aspergillosis and coexisting mycobacterial infections.

Effect of rifampin and rifabutin on serum itraconazole levels in patients with chronic pulmonary aspergillosis and coexisting nontuberculous mycobacterial infection

Moon SM, Park HY, Jeong BH, Jeon K, Lee SY, Koh WJ

Antimicrob Agents Chemother. 2015 Jan;59(1):663-5

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